Clinical Research

Synaptive Medical is dedicated to engaging our partners by supporting evidence-based studies that demonstrate the value of our BrightMatter™ solutions to hospitals and surgeons, which ultimately helps improve patient care.

Peer Reviewed Articles

  • Common Disconnections in Glioma Surgery: An Anatomic Description

    Common Disconnections in Glioma Surgery: An Anatomic Description

    Dr Michael Sughrue at University of Oklahoma Heath Sciences Center, Oklahoma City OK, presented a neurosurgical framework for maximal resection of gliomas. The foundation of the neurosurgical framework involves consideration of whole brain tractography as visualized using BrightMatter Plan.1

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  • Resection of a Pediatric Thalamic Juvenile Pilocytic Astrocytoma with Whole Brain Tractography

    Resection of a Pediatric Thalamic Juvenile Pilocytic Astrocytoma with Whole Brain Tractography

    Dr Dimitris Placantonakis at NYU School of Medicine, New York NY, reported the first pediatric application of BrightMatter Plan where the patient was living a normal life and free of tumor reoccurence at two year follow up.2

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  • Video Microscope Robotic Arm-Assisted, Neuronavigation-guided Glioma Resection and Regional Sampling

    Video Microscope Robotic Arm-Assisted, Neuronavigation-guided Glioma Resection and Regional Sampling

    Dr Ather Enam at Aga Khan Universty, Karachi Pakistan, reported a case report describing the use of BrightMatter solution in aiding the regional sampling of a heterogeneous glioma. 3

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  • White Matter Tracts in Patients with Temporal Lobe Epilepsy: Pre- and Postoperative Assessment

    White Matter Tracts in Patients with Temporal Lobe Epilepsy: Pre- and Postoperative Assessment

    Dr Terry Peters at Western University, London ON, reported a case series of 6 patients undergoing temporal lobectmoy for treatment of temporal epilepsy. BrightMatter Plan was illustrated as a preoperative tool for the lateralization of the epileptogenic focus. 4

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  • Tractography for Optic Radiation Preservation in Transcortical Approaches to Intracerebral Lesions

    Tractography for Optic Radiation Preservation in Transcortical Approaches to Intracerebral Lesions

    Dr Daniel Barrow at Emory University School of Medicine, Atlanta GA, reported a case report of a patient with intraventricular mengioma where BrightMatter Plan enabled the identification of a safe corridor to preserve their speech and visual status.5

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  • Diffusion Tensor Imaging for Ruptured Cerebral Arteriovenous Malformation

    Diffusion Tensor Imaging for Ruptured Cerebral Arteriovenous Malformation

    Dr Ather Enam at Aga Khan Universty, Karachi Pakistan, reported a case series of ruptured AVM where tractography was utlized to identify safe corridors as aided by BrightMatter Plan and BrightMatter Guide. 6

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  • Refining Surgical Corridors with Whole Brain Tractography: A Case Series

    Refining Surgical Corridors with Whole Brain Tractography: A Case Series

    Dr Gustavo Pradilla at Emory University School of Medicine, Atlanta GA, reported a case series describing the clinical use of BrightMatter Plan for intracranial brain tumors and intracerebral hemorhages. BrightMatter Plan enabled the visualization of tractography preoperative and postoperatively which aided in surgical planning and confirmation of white matter preservation.7

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  • Automated Whole Brain Tractography Affects Preoperative Surgical Decision Making

    Automated Whole Brain Tractography Affects Preoperative Surgical Decision Making

    Dr Ian Lee at Henry Ford Hospital, Detroit MI, reported a 73 patient case series describing their experience in using whole brain tractography (WBT), generated by BrightMatter Plan, in impacting their surgical decisions such as informing surgical trajectory to avoid eloquent white matter tracts to improve patient outcomes. Furthermore, WBT allowed the identification of high risk patients that benefitted from intaroperative mapping which in turn also confirmed tractography visualized by BrightMatter Plan.8

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  • The Surgical White Matter Chassis: A Practical 3-Dimensional Atlas for Planning Subcortical Surgical Trajectories

    The Surgical White Matter Chassis: A Practical 3-Dimensional Atlas for Planning Subcortical Surgical Trajectories

    Dr Amin Kassam at Aurora St Luke’s Medical Centre, Milwaukee WI, presented a 3D framework for the white matter anatomy for neurosurgical plannig of trajectory centric approaches. The framework was culminated through the experience of considering whole brain tractography from 100 awake subcortical resections that was aided by BrightMatter Plan

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  • Videoexoscopic real-time intraoperative navigation for spinal neurosurgery: a novel co-adaptation of two existing technology platforms, technical note.

    Videoexoscopic real-time intraoperative navigation for spinal neurosurgery: a novel co-adaptation of two existing technology platforms, technical note.

    Dr Holman and his colleagues at Houston Methodist, Houston TX, presents to combined used of BrightMatter Drive with a third party navigation system to allow for simulatenous visualization optical and navigation information in spine surgery.

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  • Initial experience with a robotically operated video optical telescopic-microscope in cranial neurosurgery: feasibility, safety, and clinical applications.

    Initial experience with a robotically operated video optical telescopic-microscope in cranial neurosurgery: feasibility, safety, and clinical applications.

    Dr Amin Kassam and his colleagues at Aurora St Luke’s Medical Centre, Milwaukee WI, presents a 200 patient retrospective case series of the use of BrightMatter Servo. They demonstrate that BrightMatter Servo is a viable visualization method across a wide range of neurosurgical procedures including ICHs, intraaxial and extraaxial tumors in noneloquent and eloquent areas, skull base lesions, intraventricular lesions, and cerebrovascular lesions.

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  • Advancement of Surgical Visualization Methods: Comparison Study Between Traditional Microscopic Surgery and a Novel Robotic Optoelectronic Visualization Tool for Spinal Surgery.

    Advancement of Surgical Visualization Methods: Comparison Study Between Traditional Microscopic Surgery and a Novel Robotic Optoelectronic Visualization Tool for Spinal Surgery.

    Dr Jens Chapman and his colleagues at Swedish Neuroscience Institute, Seattle WA, presented a study comparing operative microscope (OM) and BrightMatter Servo on a population of residents and fellows in a cadaveric spinal dissection model. BrightMatter Servo was found to be comparable against the OM in procedure time and the quality of the dissection and the rate of complication. However, BrightMatter Servo offered advantages such as ergonomics, ease of use, teaching potential, and higher depth of field. In conclusion, BrightMatter Servo offers a viable alternative to the OM in a spinal cadaveric setting without sacrificing on the quality and time of the procedure.9

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  • White matter tract recovery following medial temporal lobectomy and selective amygdalohippocampectomy for tumor resection

    White matter tract recovery following medial temporal lobectomy and selective amygdalohippocampectomy for tumor resection

    Dr Amin Kassam at Aurora St Luke’s Medical Centre, Milwaukee WI, presented a case report illustrating the use of the BrightMatter™ solution. Patient had seizures and a mesial temporal lobe astrocytoma that forced the inferior longitudinal fasciculus (ILF) to deviate laterally and diminished the fractional anisotropy of the uncinate fasciculus (UF) when visualized by BrightMatter™ Plan. An awake medial temporal lobectomy and selective amygdalohippocampectomy was performed where BrightMatter™ Servo’s video microscope aided in tissue differentiation and surgical resection. The patient was seizure free with no post-operative complications. Post-operative DTI with BrightMatter™ Plan revealed preservation and restoration of the inferior-fronto-occipital fasciculus, ILF, and UF.10

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  • Minimally Invasive Transsulcal Resection of Intraventricular and Periventricular Lesions Through a Tubular Retractor System: Multicentric Experience and Results.

    Minimally Invasive Transsulcal Resection of Intraventricular and Periventricular Lesions Through a Tubular Retractor System: Multicentric Experience and Results.

    A multi-center study led by Dr Julian Bailes at NorthShore University Health System, Evanston IL, performed a retrospective study of 20 patients describing the experience of presurgical planning with white matter tractography for the purposes of minimally invasive approaches. Two representative cases of a metastatic tumor and a high-grade glioma demonstrated the use of BrightMatter™ Plan to identify a minimally invasive surgical approach to maximally preserve the white matter tracts. Both patients showed a lack of post-operative deficits. 11

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  • Training Medical Novices in Spinal Microsurgery: Does the Modality Matter?

    Training Medical Novices in Spinal Microsurgery: Does the Modality Matter?

    Dr Rod Oskouian and his colleagues from Swedish Neuroscience Institute, Seattle WA, studied medically naïve individuals and compared the use of BrightMatter Servo and the surgical microscope in a cadaveric setting performing a lumbar laminotomy. The study found that there was a strong preference towards BrightMatter Servo in ergonomics, ease of use, and its potential as a training module.

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Whitepapers

  • Ependymoma

    Ependymoma

    Ian Lee, MD, FAANS, Neurosurgeon, Henry Ford Health System

    Whole Brain Tractography visualization by BrightMatter™ Plan provided critical information of the relationship between the Ependymoma in relation to the cortical spinal tract (CST) that was not present in standard MRI. This additional information informed the surgeon of the brain tumor margins which minimized loss of motor function during tumor resection. Intraoperative cortical stimulation mapping confirmed the location of the CST generated by BrightMatter™ Plan.

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  • Intracerabral Hematoma

    Intracerabral Hematoma

    Lloyd Zucker, MD, FAANS, Chief of Neurosurgery, Delray Medical Center

    Whole Brain Tractography visualization by BrightMatter™ Plan identified a corridor for surgical evacuation of an ICH. This changed the treatment management for the patient from a watchful waiting approach to a surgical evacuation approach. Post-operative DTI visualized by BrightMatter™ Plan showed evidence of tract recovery with minimal evidence of the surgical approach.

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  • High Grade Glioma

    High Grade Glioma

    Gustavo Pradilla, MD, Chief of Neurosurgery, Grady Memorial Hospital

    Whole brain tractography visualization by BrightMatter™ Plan provided new information about the relationship of the tumor and its surrounding tractography. It was found that the intended surgical approach (without tractography information) would have put critical white matter fibers at risk. Therefore, BrightMatter™ Plan changed the intended surgical approach into one that was minimally invasive with respect to white matter preservation.

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  • Glioblastoma Multiforme

    Glioblastoma Multiforme

    Gustavo Pradilla, MD, Chief of Neurosurgery, Grady Memorial

    Whole brain tractography visualization by BrightMatter™ Plan revealed that the pathology displaced surrounding white matter tracts and suggested that surgical debulking could improve the functional status of the patient in preparation for adjuvant chemoradiation. This new information provided by BrightMatter™ Plan prompted a change in disease management from an initial biopsy to a surgical debulking.

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  1. Image reprinted courtesy of Cureus Journal of Medical Science.
  2. Image reprinted courtesy of Cureus Journal of Medical Science.
  3. Image reprinted courtesy of Cureus Journal of Medical Science.
  4. Image reprinted courtesy of Cureus Journal of Medical Science.
  5. Image reprinted courtesy of Cureus Journal of Medical Science.
  6. Image reprinted courtesy of Cureus Journal of Medical Science.
  7. Image reprinted courtesy of Cureus Journal of Medical Science.
  8. Image reprinted courtesy of Cureus Journal of Medical Science.
  9. Reprinted from World Neurosurgery, Vol 98, Marc D. Moisi, Kimberly Hoang, R. Shane Tubbs, Jeni Page, Christian Fisahn, David Paulson, Shiveindra Jeyamohan, Johnny Delashaw, David Hanscom, Rod J. Oskouian, Jens Chapman, Advancement of Surgical Visualization Methods: A Comparison Study between Traditional Microscopic Surgery and a Novel Robotic Optoelectronic Visualization Tool for Spinal Surgery, Pages 273-277, Copyright 2016, with permission from Elsevier.
  10. Image reprinted from World Neurosurgery, Vol 90, Javed Khader Eliyas, Ryan Glynn, Charles G. Kulwin, Richard Rovin, Ronald Young, Juan Alzate, Gustavo Pradilla, Mitesh V. Shah, Amin Kassam, Ivan Ciric, Julian Bailes, Minimally Invasive Transsulcal Resection of Intraventricular and Periventricular Lesions Through a Tubular Retractor System: Multicentric Experience and Results, Pages 556-564, Copyright 2016, with permission from Elsevier.
  11. Reprinted from Interdisciplinary Neurosurgery, Vol 6, Srikant S. Chakravarthi, Anthony Zbacnik, Jonathan Jennings, Melanie B. Fukui, Nathaniel Kojis, Richard A. Rovin, Amin B. Kassam, White matter tract recovery following medial temporal lobectomy and selective amygdalohippocampectomy for tumor resection via a ROVOT-m port-guided technique: A case report and review of literature, Pages 55-61, Copyright 2016, with permission from Elsevier.